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German Medical Monthly

Editor of the English Language Edition:
G. R. GRAHAM, LONDON
Board of Editorial Consultants: L. Heilmeyer
Ulm/Donau, Chairman
GEORG THIEME VERLAG – STUTTGART

Vol. XIII                                                   Stuttgart, March 1968                        No. 3, page 111‑116

The Thrombolytic Therapy of Recent Myocardial Infarction1

Ill. Overall Assessment and Evaluation of Enzyme Studies

P. Körtge, F. Praetorius, B. Schneider, F. Heckner, J. van de Loo, F. A. Pezold, H. Poliwoda, R. Schmutzler and D. Zekorn

Abstract:
A cooperative study was undertaken at six medical centres to assess the effect of thrombolytic therapy on the course of recent myocardial infarcts in comparison with anticoagulant therapy alone. The drop in mortality rate from 21.7 % to 14.1 %, the more rapid regression of ECG changes and the more rapid rise in serum enzyme activity1) were evidence of the favourable effect of thrombolytic therapy.

Zusammenfassung:
In einer vergleichenden Gemeinschaftsstudie von sechs Kliniken wurde der Einfluß einer thrombolytischen Therapie des frischen Myokardinfarktes auf den Verlauf der Erkrankung im Vergleich mit einer Antikoagulantientherapie geprüft. Die Senkung der Letalität von 21,7 % auf 14,1 %, der raschere Ablauf der elektrokardiographischen Veränderungen und der schnellere Anstieg der Enzymaktivitäten lassen einen günstigen Einfluß der Behandlung erkennen.

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1) At first:
Praetorius F,  Körtge P: Thrombolysis in Myocardial Infarction, Response of Serum Enzymes.  

ANGIOLOGY 17: 640–643, 1966

The revised 36 patients belong to the total collection presented in German Medical Monthly, see above. One group of patients received treatment at a sufficiently early time, 1-3 hours after the onset of the infarction. This is compared with patients in whom fibrinolytic therapy was started 3 hours or later after the onset of the infarction. A total of 349 measurements (SGOT: 208, CPK: 141) were taken in intervals of 3-24 hours. During the early phase, there seems to be a definite difference with higher levels in the early treated group and the point of maximum occurring later in the later treated patients. The difference was significant (p < 0.01, p < 0.02) at a point 4 hours (CPK) respectively 6 hours (SGOT) after the onset of infarction. The earlier increase of serum enzymes may demonstrate a measurable action of the fibrinolytic therapy.

   Angiology 1966
1966

 

 Correspondence and offprint requests to Dr. Frank Praetorius

 

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